Trial Type: Gastric Cancer

CAST
A Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD4360, a TOP1i ADC Targeting Claudin 18.2 (CLDN18.2) in Adult Participants with Advanced Solid Tumors
Contact: Alex Raufi, MD
LUCERNA
A Phase 3, Double-Blind, Randomized Study of Zolbetuximab in Combination with Pembrolizumab and Chemotherapy (CAPOX or mFOLFOX6) in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma in Participants Whose Tumors are HER2-negative, Claudin (CLDN) 18.2-positive and PD-L1-positive
Status: Open
Contact: Alex Raufi, MD
Destiny 205
A Phase 1b/2, Multicenter, Open-label Trial of DS-9606a, a CLDN6-directed Antibody drug Conjugate for Individuals with Advanced Solid Tumors
Status: Open
Contact: Alex Raufi, MD
CAPE
A Phase II, Open-label, Multi-centre Study to Evaluate Safety, Tolerability, Efficacy, PK, and Immunogenicity of AZD0901 as Monotherapy and in Combination with Anti-cancer Agents in Participants with Advanced Solid Tumours Expressing Claudin 18.2
Status: Open
Contact: Alex Raufi, MD
HAT
A Phase 1 Study of NM32-2668 (Anti ROR1/Anti CD3/Anti-HSA Tri-Specific Antibody) in Adult Patients with Selected Advanced Solid Tumors
Contact: Benedito Carneiro, MD
DisTinGuish
DKN-01, Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy for metastatic gastric and esophageal cancer
Status: Open
Trial Type: Gastric Cancer
Contact: Khaldoun Almhanna, MD
TIDE
inhibitor of MTAP for patients with MTAP gene alterations in gastric esophageal, NSCLC and bladder cancer
Contact: Benedito Carneiro, MD