Trial Type: Head and Neck

LS-P-MAST
A Phase 1/2, Open Label, First-in-human, Dose Escalation and Expansion Study for the Evaluation of Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of SAR445877 Administered as Monotherapy or in Combination With Other Anticancer Therapies in Adults With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Gastrointestinal, Head and Neck, Thoracic
Contact: Almhanna, Khaldoun
kalmhanna@BrownHealth.org
BH-P-LAMP
A Phase 1, Open-label, Multicenter, First-in-Human Trial of DS5361b in Participants With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-PAINT
ACR-2316-101: Phase 1 Study of ACR-2316 in Subjects With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
SWOGS2205
Ice Compress: Randomized Trial of Limb Cryocompression Versus Continuous Compression Versus Low Cyclic Compression for the Prevention of Taxane-Induced Peripheral Neuropathy
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Eye, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Lymphoma, Musculoskeletal, Neurologic, Skin, Thoracic, Unknown Primary
Contact: Graff, Stephanie
sgraff1@BrownHealth.org
BH-P-CEDER
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of NDI-219216 in Patients With Advanced Solid Tumors With/Without Microsatellite Instability and/or Deficient Mismatch Repair
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Musculoskeletal, Neurologic, Other Hematology, Skin, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-M20-431
A Phase 1 Study With ABBV-CLS-484 Alone and in Combination in Subjects With Locally Advanced or Metastatic Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Genitourinary, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-POPPY
A First-in-Human, Open-label, Multicenter, Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PYX-201 in Participants With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-MYTHIC
Phase 1/1b Study of the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Activity of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Skin, Thoracic, Unknown Primary
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-HEAT
First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFβ Fusion Protein BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-Driven Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Endocrine Neuroendocrine, Gastrointestinal, Head and Neck, Skin, Thoracic
Contact: Birnbaum, Ariel
abirnbaum@BrownHealth.org
LS-P-PRIMROSE
PRIMROSE: A Modular Phase I/IIa, Multi-centre, Dose Escalation, and Expansion Study of AZD3470, a MTA Cooperative PRMT5 Inhibitor, as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced/Metastatic Solid Tumors That Are MTAP Deficient
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Genitourinary, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org