Trial Type: Gastrointestinal

LS-P-HEAT
First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFβ Fusion Protein BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-Driven Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Endocrine Neuroendocrine, Gastrointestinal, Head and Neck
Contact: Birnbaum, Ariel
abirnbaum@BrownHealth.org
BH-P-RAIN
A Phase Ia/Ib Open-label, Dose-escalation Study to Evaluate the Safety and Pharmacokinetics of ROSE12 as a Single Agent and in Combination With Other Anti-tumor Agents in Patients With Locally Advanced or Metastatic Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Thoracic
Contact: Safran, Howard
hsafran@BrownHealth.org
LS-P-PATH
A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Thoracic
Contact: Safran, Howard
hsafran@BrownHealth.org
LS-P-CAPE
A Phase II, Open-label, Multi-centre Study to Evaluate Safety, Tolerability, Efficacy, PK, and Immunogenicity of AZD0901 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Tumours Expressing Claudin 18.2 (CLARITY-PanTumour01)
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Raufi, Alexander
araufi2@BrownHealth.org
SWOGS2205
Ice Compress: Randomized Trial of Limb Cryocompression Versus Continuous Compression Versus Low Cyclic Compression for the Prevention of Taxane-Induced Peripheral Neuropathy
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Eye, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Lymphoma, Musculoskeletal, Neurologic, Skin, Thoracic, Unknown Primary
Contact: Graff, Stephanie
sgraff1@BrownHealth.org
LS-P-MAST
A Phase 1/2, Open Label, First-in-human, Dose Escalation and Expansion Study for the Evaluation of Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of SAR445877 Administered as Monotherapy or in Combination With Other Anticancer Therapies in Adults With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Gastrointestinal, Head and Neck, Thoracic
Contact: Almhanna, Khaldoun
kalmhanna@BrownHealth.org
BH-P-CONCLUDE
A Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD4360 in Adult Participants With Advanced Solid Tumours
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Raufi, Alexander
araufi2@BrownHealth.org
LS-P-PRIMROSE
PRIMROSE: A Modular Phase I/IIa, Multi-centre, Dose Escalation, and Expansion Study of AZD3470, a MTA Cooperative PRMT5 Inhibitor, as Monotherapy and in Combination With Anticancer Agents in Patients With Advanced/Metastatic Solid Tumors That Are MTAP Deficient
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Genitourinary, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-OCEAN
A Phase I, Multicenter, Open-Label First in Human Study of Anti-CEACAM5 Antibody Drug Conjugate M9140 in Participants With Advanced Solid Tumors (PROCEADE-CRC-01)
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Breakstone, Rimini
rimini.breakstone@BrownHealth.org
BH-P-FLOAT
A Phase I, First-in-human, Open-label, Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BNT317 in Patients With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Musculoskeletal, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org