Trial Type: Gastrointestinal

LS-P-HEAT
First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFβ Fusion Protein BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-Driven Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Contact: Birnbaum, Ariel
LS-P-PAINT
ACR-2316-101: Phase 1 Study of ACR-2316 in Subjects With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Contact: Carneiro, Benedito
BH-P-ENACT
A Phase 2 Study to Investigate the Efficacy and Safety of Acoustic Cluster Therapy With Modified FOLFIRINOX in Patients With Locally Advanced Pancreatic Cancer
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Raufi, Alexander
LS-P-IMPACT
A First-in-human, Phase 1/2, Open-label, Multi-center, Dose-escalation, Dose-optimization, and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of PARP1 Selective Inhibitor, IMP1734, as Monotherapy in Patients With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Contact: Carneiro, Benedito
LS-P-CAPE
A Phase II, Open-label, Multi-centre Study to Evaluate Safety, Tolerability, Efficacy, PK, and Immunogenicity of AZD0901 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Tumours Expressing Claudin 18.2 (CLARITY-PanTumour01)
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Raufi, Alexander
BH-P-HARMONI-GI3
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination With FOLFOX Versus Bevacizumab in Combination With FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Breakstone, Rimini
BH-P-SPRINT
An Early Phase Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of PEEL-224 in Patients With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Safran, Howard
CMC-CHEMO4METPANC
A Phase 2 Study With Combination Chemotherapy (Gemcitabine and Nab-Paclitaxel), Chemokine (C-X-C) Motif Receptor 4 Inhibitor (BL-8040), and Immune Checkpoint Blockade (Cemiplimab) in METastatic Treatment naïve PANCreas Adenocarcinoma
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal
Contact: Raufi, Alexander
ALTE2131
Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults With Cancer
Protocol Status: OPEN TO ACCRUAL
Contact: DeNardo, Bradley
BH-P-CEDER
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of NDI-219216 in Patients With Advanced Solid Tumors With/Without Microsatellite Instability and/or Deficient Mismatch Repair
Protocol Status: OPEN TO ACCRUAL
Contact: Carneiro, Benedito