Trial Type: Thoracic

LS-P-PATH
A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Thoracic
Contact: Safran, Howard
hsafran@BrownHealth.org
BH-P-RAIN
A Phase Ia/Ib Open-label, Dose-escalation Study to Evaluate the Safety and Pharmacokinetics of ROSE12 as a Single Agent and in Combination With Other Anti-tumor Agents in Patients With Locally Advanced or Metastatic Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Thoracic
Contact: Safran, Howard
hsafran@BrownHealth.org
BRUOG-431
Prevention of Datopotamab Deruxtecan (TROP-2 Directed ADC) Associated Stomatitis in Patients With HER2-negative Metastatic Breast Cancer or Non-small Cell Lung Cancer Using Dexamethasone Mouthwash: a Single-arm, Phase 2 Trial (TROPION- DM, 2023-ESR-000087)
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Thoracic
Contact: Graff, Stephanie
sgraff1@BrownHealth.org
SWOGS2205
Ice Compress: Randomized Trial of Limb Cryocompression Versus Continuous Compression Versus Low Cyclic Compression for the Prevention of Taxane-Induced Peripheral Neuropathy
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Eye, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Lymphoma, Musculoskeletal, Neurologic, Skin, Thoracic, Unknown Primary
Contact: Graff, Stephanie
sgraff1@BrownHealth.org
LS-P-COAST
A Phase 1, 2-Part, Multicenter, First-In-Human Dose-Escalation and Dose-Expansion Study of DS-1103a Combination Therapy in Subjects With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Thoracic
Contact: Graff, Stephanie
sgraff1@BrownHealth.org
LS-P-MAST
A Phase 1/2, Open Label, First-in-human, Dose Escalation and Expansion Study for the Evaluation of Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of SAR445877 Administered as Monotherapy or in Combination With Other Anticancer Therapies in Adults With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Gastrointestinal, Head and Neck, Thoracic
Contact: Almhanna, Khaldoun
kalmhanna@BrownHealth.org
LS-P-FONTANA
A Modular Phase I/IIa, Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Ascending Doses of AZD5335 Monotherapy and in Combination With Anti-cancer Agents in Participants With Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gynecologic, Thoracic
Contact: Khan, Hina
hina.khan@BrownHealth.org
LS-P-PRIMROSE
PRIMROSE: A Modular Phase I/IIa, Multi-centre, Dose Escalation, and Expansion Study of AZD3470, a MTA Cooperative PRMT5 Inhibitor, as Monotherapy and in Combination With Anticancer Agents in Patients With Advanced/Metastatic Solid Tumors That Are MTAP Deficient
Protocol Status: OPEN TO ACCRUAL
Trial Type: Gastrointestinal, Genitourinary, Head and Neck, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org
LS-P-NEO-EMPOWER
A Randomized Phase 2 Platform Study to Evaluate Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for the Perioperative Treatment of Patients With Resectable Non-Small Cell Lung Cancer
Protocol Status: OPEN TO ACCRUAL
Trial Type: Thoracic
Contact: Azzoli, Christopher
cazzoli@BrownHealth.org
BH-P-FLOAT
A Phase I, First-in-human, Open-label, Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BNT317 in Patients With Advanced Solid Tumors
Protocol Status: OPEN TO ACCRUAL
Trial Type: Breast, Endocrine Neuroendocrine, Gastrointestinal, Genitourinary, Gynecologic, Head and Neck, Musculoskeletal, Thoracic
Contact: Carneiro, Benedito
benedito.carneiro@BrownHealth.org